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KMID : 1197720220150010001
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대한파킨슨병 및 이상운동질환 학회지
2022 Volume.15 No. 1 p.1 ~ p.14
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Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
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Lai Thuy Thi
Kim Yun-Joong
Ma Hyeo-Il
Kim Young-Eun
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Abstract
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Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis of PD. Thus, achieving a better understanding of the interaction between inflammation and synucleinopathy in relation to the PD process will facilitate the development of promising disease-modifying therapies. In this review, the evidence of inflammation in PD is discussed, and human, animal, and laboratory studies relevant to the relationship between inflammation and αSyn are explored as well as new therapeutic targets associated with this relationship.
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KEYWORD
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Alpha-synuclein, Astrocyte, Inflammation, Lymphocyte, Microglia, Parkinson’s disease
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